Drug Developers Take Aim at 'Guided-Missile' Cancer Drugs
2020-01-10
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1Companies are testing a record 89 treatments on humans to fight cancer.
2These treatments combine antibodies from the body's natural defense system with agents that fight cancer.
3They are testing what they call antibody-drug conjugates, or ADCs.
4Researchers describe ADCs as "guided missiles" in the fight against cancer.
5They are designed to target cancer cells and then release cytotoxins - substances that have a toxic or poisonous effect on the cells.
6ADCs are up to 10,000 times as powerful as most chemotherapy treatments.
7They also reduce damage to healthy tissue.
8Developing ADCs has been a major aim for the biotechnology industry for years.
9Many experimental ADCs, however, failed because of the difficulty of combining the right antibody with the right cancer-killing substance.
10Some ADCs were found to be too weak.
11 Others were too harmful.
12From 2000 to 2018, only five ADCs won official approval.
13Only one ADC, developed by drug maker Roche, has reached $1 billion in yearly sales.
14It was approved in 2013 to treat breast cancer.
15Studies showed the drug increased the chances of disease-free survival for some patients compared with the usual treatment.
16In 2019, U.S. officials approved three ADCs, the most ever in a single year.
17One of them was the breast cancer drug Enhertu, developed by AstraZeneca and Daiichi Sankyo.
18It was shown to help patients who had failed numerous treatments.
19The drug helped them survive more than 16 months on average before their disease worsened.
20Padcev, a bladder cancer drug, received approval in December.
21Research showed that 44% of patients who had failed immunotherapy showed improvement when they were tested after treatment.
22In some cases, patients showed no evidence of cancer.
23The drug is a product of two companies, Astellas and Seattle Genetics.
24Another drug, Polivy, was approved in June to treat lymphoma.
25When combined with two other treatments, 40% of patients showed no sign of disease.
26Polivy is a product of the Swiss drug maker Roche.
27Reuters news agency says the biotechnology industry is growing hopeful about the effectiveness of ADCs.
28Information provided by Beacon Targeted Therapies shows that the number of ADC drug candidates is at record levels.
29Many more ADCs are being considered before human testing is permitted.
30Beacon advises drug makers on targeted treatments.
31The service helps them decide whether to continue working on possible drugs or redirect efforts.
32Current ADC projects include GlaxoSmithKline testing a drug to fight multiple myeloma.
33ADC Therapeutics has launched several studies on experimental drugs for treating blood cancers and solid tumors.
34And ImmunoGen, based in the American state of Massachusetts, is developing an ADC to treat ovarian cancer.
35In December, the U.S. Food and Drug Administration said the drug might become a candidate for a faster than normal approval.
36The increase in ADC investment is partly because of improvements in what researchers are calling "linker" technology.
37The linker joins the antibody to the cancer-killing cytotoxins.
38Giuseppe Curigliano is clinical director of early drug development at the European Institute of Oncology in Milan.
39He told Reuters, "There is a revival again because there is a new generation of molecules in which the linker is more efficient."
40I'm Anne Ball.
1Companies are testing a record 89 treatments on humans to fight cancer. These treatments combine antibodies from the body's natural defense system with agents that fight cancer. 2They are testing what they call antibody-drug conjugates, or ADCs. 3Researchers describe ADCs as "guided missiles" in the fight against cancer. They are designed to target cancer cells and then release cytotoxins - substances that have a toxic or poisonous effect on the cells. 4ADCs are up to 10,000 times as powerful as most chemotherapy treatments. They also reduce damage to healthy tissue. 5Developing ADCs has been a major aim for the biotechnology industry for years. Many experimental ADCs, however, failed because of the difficulty of combining the right antibody with the right cancer-killing substance. Some ADCs were found to be too weak. Others were too harmful. 6From 2000 to 2018, only five ADCs won official approval. Only one ADC, developed by drug maker Roche, has reached $1 billion in yearly sales. It was approved in 2013 to treat breast cancer. Studies showed the drug increased the chances of disease-free survival for some patients compared with the usual treatment. 7In 2019, U.S. officials approved three ADCs, the most ever in a single year. One of them was the breast cancer drug Enhertu, developed by AstraZeneca and Daiichi Sankyo. It was shown to help patients who had failed numerous treatments.The drug helped them survive more than 16 months on average before their disease worsened. 8Padcev, a bladder cancer drug, received approval in December. Research showed that 44% of patients who had failed immunotherapy showed improvement when they were tested after treatment. In some cases, patients showed no evidence of cancer. The drug is a product of two companies, Astellas and Seattle Genetics. 9Another drug, Polivy, was approved in June to treat lymphoma. When combined with two other treatments, 40% of patients showed no sign of disease. Polivy is a product of the Swiss drug maker Roche. 10New record 11Reuters news agency says the biotechnology industry is growing hopeful about the effectiveness of ADCs. 12Information provided by Beacon Targeted Therapies shows that the number of ADC drug candidates is at record levels. Many more ADCs are being considered before human testing is permitted. 13Beacon advises drug makers on targeted treatments. The service helps them decide whether to continue working on possible drugs or redirect efforts. 14Current ADC projects include GlaxoSmithKline testing a drug to fight multiple myeloma. 15ADC Therapeutics has launched several studies on experimental drugs for treating blood cancers and solid tumors. 16And ImmunoGen, based in the American state of Massachusetts, is developing an ADC to treat ovarian cancer. In December, the U.S. Food and Drug Administration said the drug might become a candidate for a faster than normal approval. 17The increase in ADC investment is partly because of improvements in what researchers are calling "linker" technology. The linker joins the antibody to the cancer-killing cytotoxins. 18Giuseppe Curigliano is clinical director of early drug development at the European Institute of Oncology in Milan. He told Reuters, "There is a revival again because there is a new generation of molecules in which the linker is more efficient." 19I'm Anne Ball. 20Ludwig Burger and John Miller reported this story for the Associated Press. Jonathan Evans adapted it for VOA Learning English. George Grow was the editor. 21What do you think of this story? Leave a comment below. 22_________________________________________________________________ 23Words in This Story 24chemotherapy - n. the use of chemical agents to treat disease 25immunotherapy - n. treatment or prevention of disease that involved suppression or strengthening the body's natural defenses against disease